This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3us4
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3us4' size='340' side='right'caption='[[3us4]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='3us4' size='340' side='right'caption='[[3us4]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3us4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3us4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3US4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3US4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | ||
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us4 OCA], [https://pdbe.org/3us4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us4 RCSB], [https://www.ebi.ac.uk/pdbsum/3us4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us4 OCA], [https://pdbe.org/3us4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us4 RCSB], [https://www.ebi.ac.uk/pdbsum/3us4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/MATK_HUMAN MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.<ref>PMID:9171348</ref> | |
==See Also== | ==See Also== | ||
| Line 19: | Line 16: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Non-specific protein-tyrosine kinase]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: TCELL, Partnership for T-Cell Biology]] | ||
| - | [[Category: Jcsg]] | ||
| - | [[Category: Partnership for t-cell biology]] | ||
| - | [[Category: PSI, Protein structure initiative]] | ||
| - | [[Category: Psi-biology]] | ||
| - | [[Category: Sh2 domain]] | ||
| - | [[Category: Signaling protein]] | ||
| - | [[Category: Tcell]] | ||
| - | [[Category: Transferase]] | ||
Current revision
Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution
| |||||||||||
