3uv0

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Current revision (08:39, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3uv0' size='340' side='right'caption='[[3uv0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3uv0' size='340' side='right'caption='[[3uv0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV0 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mu2, Dmel_CG1960 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv0 OCA], [https://pdbe.org/3uv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv0 OCA], [https://pdbe.org/3uv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv0 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9W061_DROME Q9W061_DROME]
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Mutator 2 (MU2) in Drosophila melanogaster has been proposed to be the ortholog of human MDC1, a key mediator in DNA damage response. The forkhead-associated (FHA) domain of MDC1 is a dimerization module regulated by trans binding to phosphothreonine 4 from another molecule. Here we present the crystal structure of the MU2 FHA domain at 1.9A resolution, revealing its evolutionarily conserved role in dimerization. As compared to the MDC1 FHA domain, the MU2 FHA domain dimerizes using a different and more stable interface and contains a degenerate phosphothreonine-binding pocket. Our results suggest that the MU2 dimerization is constitutive and lacks phosphorylation-mediated regulation. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: MU2 and MU2bind by cosedimentation in solution (View interaction) MU2 and MU2bind by X-ray crystallography (View interaction) MU2 and MU2bind by molecular sieving (View interaction).
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Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1.,Luo S, Ye K FEBS Lett. 2012 Feb 17;586(4):344-9. Epub 2012 Jan 21. PMID:22273583<ref>PMID:22273583</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3uv0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Luo, S]]
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[[Category: Luo S]]
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[[Category: Ye, K]]
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[[Category: Ye K]]
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[[Category: Dimerization]]
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[[Category: Fha]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of the drosophila MU2 FHA domain

PDB ID 3uv0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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