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1hqr

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[[Image:1hqr.gif|left|200px]]
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{{Seed}}
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[[Image:1hqr.png|left|200px]]
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{{STRUCTURE_1hqr| PDB=1hqr | SCENE= }}
{{STRUCTURE_1hqr| PDB=1hqr | SCENE= }}
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'''CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II'''
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===CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II===
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==Overview==
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MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-affinity site on the alpha chain and a high-affinity, zinc-dependent site on the beta chain. Only the former has been defined crystallographically. We report the structure of streptococcal pyrogenic exotoxin C (SPE-C) complexed with HLA-DR2a (DRA*0101, DRB5*0101) bearing a self-peptide from myelin basic protein (MBP). SPE-C binds the beta chain through a zinc bridge that links the SAG and class II molecules. Surprisingly, SPE-C also makes extensive contacts with the MBP peptide, such that peptide accounts for one third of the surface area of the MHC molecule buried in the complex, similar to TCR-peptide/MHC complexes. Thus, SPE-C may optimize T cell responses by mimicking the peptide dependence of conventional antigen presentation and recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_11163233}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11163233 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11163233}}
==About this Structure==
==About this Structure==
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[[Category: Schlievert, P.]]
[[Category: Schlievert, P.]]
[[Category: Superantigen-mhc class ii complex]]
[[Category: Superantigen-mhc class ii complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:08:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:33:20 2008''

Revision as of 05:33, 1 July 2008

Image:1hqr.png

Template:STRUCTURE 1hqr

CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II

Template:ABSTRACT PUBMED 11163233

About this Structure

1HQR is a Protein complex structure of sequences from Homo sapiens and Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II., Li Y, Li H, Dimasi N, McCormick JK, Martin R, Schuck P, Schlievert PM, Mariuzza RA, Immunity. 2001 Jan;14(1):93-104. PMID:11163233

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