3v7f

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Current revision (08:39, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3v7f' size='340' side='right'caption='[[3v7f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3v7f' size='340' side='right'caption='[[3v7f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strp1 Strp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V7F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M1 Streptococcus pyogenes serotype M1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V7F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3toc|3toc]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">csn2, M5005_Spy0772, SPy_1049 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301447 STRP1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7f OCA], [https://pdbe.org/3v7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v7f RCSB], [https://www.ebi.ac.uk/pdbsum/3v7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7f OCA], [https://pdbe.org/3v7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v7f RCSB], [https://www.ebi.ac.uk/pdbsum/3v7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CSN2_STRP1 CSN2_STRP1]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). Binds dsDNA, binding is disrupted by EGTA.
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[https://www.uniprot.org/uniprot/CSN2_STRP1 CSN2_STRP1] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). Binds dsDNA, binding is disrupted by EGTA.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute a microbial immune system against invading genetic elements, such as plasmids and phages. Csn2 is an Nmeni subtype-specific Cas protein, and was suggested to function in the adaptation process, during which parts of foreign nucleic acids are integrated into the host microbial genome to enable immunity against future invasion. Here, we report a 2.2 A crystal structure of Streptococcus pyogenes Csn2. The structure revealed previously unseen calcium-dependent conformational changes in its tertiary and quaternary structure. This supports the proposed double-stranded DNA-binding function of S. pyogenes Csn2.
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Crystal Structure of Streptococcus pyogenes Csn2 Reveals Calcium-Dependent Conformational Changes in Its Tertiary and Quaternary Structure.,Koo Y, Jung DK, Bae E PLoS One. 2012;7(3):e33401. Epub 2012 Mar 30. PMID:22479393<ref>PMID:22479393</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v7f" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Strp1]]
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[[Category: Streptococcus pyogenes serotype M1]]
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[[Category: Bae, E]]
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[[Category: Bae E]]
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[[Category: Jung, D K]]
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[[Category: Jung DK]]
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[[Category: Koo, Y]]
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[[Category: Koo Y]]
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[[Category: Calcium binding]]
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[[Category: Dna binding protein]]
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Current revision

Crystal Structure of Streptococcus pyogenes Csn2

PDB ID 3v7f

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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