1hrj

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[[Image:1hrj.jpg|left|200px]]
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{{STRUCTURE_1hrj| PDB=1hrj | SCENE= }}
{{STRUCTURE_1hrj| PDB=1hrj | SCENE= }}
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'''HUMAN RANTES, NMR, 13 STRUCTURES'''
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===HUMAN RANTES, NMR, 13 STRUCTURES===
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==Overview==
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The solution structure of the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) has been determined using NMR spectroscopy. Backbone and side-chain 1H and 15N assignments have been obtained using a combination of two-dimensional homonuclear and three-dimensional heteronuclear spectra. Regular elements of secondary structure have been identified on the basis of a qualitative interpretation of NOE data, J(NH-H alpha) coupling constants, and amide exchange rates. Three-dimensional structures were calculated from a total of 2146 experimental restraints using a combination of distance geometry and simulated annealing protocols. For the 13 best structures the average backbone (N, C alpha, C) atomic rmsd from the mean coordinates for residues 5-65 is 0.64 A (+/- 0.14 A) for the dimer and 0.50 A (+/- 0.08 A) for the individual monomers. Each monomer consists of a three-stranded antiparallel beta-sheet (residues 26-30, 38-43, 48-51) in a Greek key motif with a C-terminal helix (56-65) packed across the sheet, an arrangement similar to the monomeric structure of other members of this chemokine family (IL-8, PF4, MGSA/Gro alpha, and MIP-1 beta). Overall, the RANTES dimer resembles that previously reported for MIP-1 beta.
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The line below this paragraph, {{ABSTRACT_PUBMED_7542919}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7542919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7542919}}
==About this Structure==
==About this Structure==
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1HRJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRJ OCA].
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1HRJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRJ OCA].
==Reference==
==Reference==
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[[Category: Wells, T N.C.]]
[[Category: Wells, T N.C.]]
[[Category: Cc chemokine]]
[[Category: Cc chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:09:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:35:18 2008''

Revision as of 05:35, 1 July 2008

Image:1hrj.png

Template:STRUCTURE 1hrj

HUMAN RANTES, NMR, 13 STRUCTURES

Template:ABSTRACT PUBMED 7542919

About this Structure

1HRJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The three-dimensional solution structure of RANTES., Chung CW, Cooke RM, Proudfoot AE, Wells TN, Biochemistry. 1995 Jul 25;34(29):9307-14. PMID:7542919

Page seeded by OCA on Tue Jul 1 08:35:18 2008

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