7p6n
From Proteopedia
(Difference between revisions)
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==ROCK2 IN COMPLEX WITH COMPOUND 12== | ==ROCK2 IN COMPLEX WITH COMPOUND 12== | ||
| - | <StructureSection load='7p6n' size='340' side='right'caption='[[7p6n]]' scene=''> | + | <StructureSection load='7p6n' size='340' side='right'caption='[[7p6n]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7p6n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6N FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6n OCA], [https://pdbe.org/7p6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6n RCSB], [https://www.ebi.ac.uk/pdbsum/7p6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6n ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YS:~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide'>5YS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6n OCA], [https://pdbe.org/7p6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6n RCSB], [https://www.ebi.ac.uk/pdbsum/7p6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ROCK2_HUMAN ROCK2_HUMAN]] Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.<ref>PMID:10579722</ref> <ref>PMID:15699075</ref> <ref>PMID:16574662</ref> <ref>PMID:17015463</ref> <ref>PMID:19131646</ref> <ref>PMID:19997641</ref> <ref>PMID:21084279</ref> <ref>PMID:21147781</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Maillard MC]] | [[Category: Maillard MC]] | ||
Revision as of 04:10, 8 September 2022
ROCK2 IN COMPLEX WITH COMPOUND 12
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