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1hrs

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{{STRUCTURE_1hrs| PDB=1hrs | SCENE= }}
{{STRUCTURE_1hrs| PDB=1hrs | SCENE= }}
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'''A CRYSTALLOGRAPHIC STUDY OF HAEM BINDING TO FERRITIN'''
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===A CRYSTALLOGRAPHIC STUDY OF HAEM BINDING TO FERRITIN===
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==Overview==
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Ferritin, the iron-storage protein, binds porphyrins, metalloporphyrins and the fluorescent dyes ANS (8-anilino-1-naphthalenesulfonic acid) and TNS (2-p-toluidinyl-6-naphthalenesulfonic acid), similarly to apo-myoglobin. Octahedral crystals of horse-spleen apo-ferritin (HSF; 174 amino acids) complexes prepared by the addition of haem, hematoporphyrin or Sn-protoporphyrin IX to a solution of apo-ferritin crystallize in space group F432 with cell parameter a = 184.0 A. X-ray crystallographic analysis of single crystals prepared from a mixture containing haem or Sn-protoporphyrin IX shows that the haem-binding sites in these crystals are occupied by protoporphyrin IX, which is free of metal, rather than by the original metalloporphyrin. The present paper describes the structure of horse-spleen apo-ferritin cocrystallized with Sn-protoporphyrin IX. The 6797 reflections up to 2.6 A resolution used in the refinement were obtained from a data set recorded on a Nicolet/Xentronics area detector with Cu Kalpha radiation from a Rigaku RU 200 rotating anode. The final structure comprises 1613 non-H atoms, two Cd atoms and 170 solvent molecules. Four residues are described as disordered. The root-mean-square deviations from ideal bond lengths and angles are 0.013 A and 2.88 degrees, respectively. Protoporphyrins are observed in special positions on the twofold axes of the ferritin molecule with a stoichiometry of 0.4 per subunit.
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{{ABSTRACT_PUBMED_15299370}}
==About this Structure==
==About this Structure==
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[[Category: Yariv, J.]]
[[Category: Yariv, J.]]
[[Category: Iron storage]]
[[Category: Iron storage]]
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Revision as of 05:36, 1 July 2008

Image:1hrs.png

Template:STRUCTURE 1hrs

A CRYSTALLOGRAPHIC STUDY OF HAEM BINDING TO FERRITIN

Template:ABSTRACT PUBMED 15299370

About this Structure

1HRS is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

A crystallographic study of haem binding to ferritin., Precigoux G, Yariv J, Gallois B, Courseille C, d'Estaintot BL, Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):739-43. PMID:15299370

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