1hs6

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[[Image:1hs6.gif|left|200px]]
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{{Seed}}
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[[Image:1hs6.png|left|200px]]
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{{STRUCTURE_1hs6| PDB=1hs6 | SCENE= }}
{{STRUCTURE_1hs6| PDB=1hs6 | SCENE= }}
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'''STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.'''
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===STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.===
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==Overview==
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Leukotriene (LT) A(4) hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc enzyme that catalyzes the biosynthesis of LTB4, a potent lipid chemoattractant involved in inflammation, immune responses, host defense against infection, and PAF-induced shock. The high resolution crystal structure of LTA4H in complex with the competitive inhibitor bestatin reveals a protein folded into three domains that together create a deep cleft harboring the catalytic Zn(2+) site. A bent and narrow pocket, shaped to accommodate the substrate LTA(4), constitutes a highly confined binding region that can be targeted in the design of specific anti-inflammatory agents. Moreover, the structure of the catalytic domain is very similar to that of thermolysin and provides detailed insight into mechanisms of catalysis, in particular the chemical strategy for the unique epoxide hydrolase reaction that generates LTB(4).
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The line below this paragraph, {{ABSTRACT_PUBMED_11175901}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11175901 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11175901}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta protein]]
[[Category: Alpha-beta protein]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:10:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:36:44 2008''

Revision as of 05:36, 1 July 2008

Image:1hs6.png

Template:STRUCTURE 1hs6

STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.

Template:ABSTRACT PUBMED 11175901

About this Structure

1HS6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation., Thunnissen MM, Nordlund P, Haeggstrom JZ, Nat Struct Biol. 2001 Feb;8(2):131-5. PMID:11175901

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