This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3vad

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:34, 1 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3vad' size='340' side='right'caption='[[3vad]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3vad' size='340' side='right'caption='[[3vad]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3vad]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VAD FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3vad]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VAD FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0F1:3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>0F1</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bckdk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0F1:3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>0F1</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vad OCA], [https://pdbe.org/3vad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vad RCSB], [https://www.ebi.ac.uk/pdbsum/3vad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vad ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vad OCA], [https://pdbe.org/3vad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vad RCSB], [https://www.ebi.ac.uk/pdbsum/3vad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vad ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
+
[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ahmed, K]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Chuang, D T]]
+
[[Category: Ahmed K]]
-
[[Category: Chuang, J L]]
+
[[Category: Chuang DT]]
-
[[Category: Gui, W J]]
+
[[Category: Chuang JL]]
-
[[Category: Tso, S C]]
+
[[Category: Gui WJ]]
-
[[Category: Wynn, R M]]
+
[[Category: Tso SC]]
-
[[Category: Allosteric kinase inhibitor]]
+
[[Category: Wynn RM]]
-
[[Category: Bergerat nucleotide-binding fold]]
+
-
[[Category: Branched-chain alpha-ketoacid]]
+
-
[[Category: Branched-chain amino acid]]
+
-
[[Category: Diabetes and obesity]]
+
-
[[Category: Ghkl protein kinase]]
+
-
[[Category: Maple syrup urine disease]]
+
-
[[Category: Protein kinase]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid

PDB ID 3vad

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vad"
Personal tools