3vdp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:39, 20 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3vdp' size='340' side='right'caption='[[3vdp]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='3vdp' size='340' side='right'caption='[[3vdp]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3vdp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cals4 Cals4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDP FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3vdp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VDP FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.451&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vds|3vds]], [[3vdt|3vdt]], [[3vdu|3vdu]], [[3ve5|3ve5]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">recR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273068 CALS4])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdp OCA], [https://pdbe.org/3vdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdp RCSB], [https://www.ebi.ac.uk/pdbsum/3vdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vdp OCA], [https://pdbe.org/3vdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vdp RCSB], [https://www.ebi.ac.uk/pdbsum/3vdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vdp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/RECR_CALS4 RECR_CALS4]] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.[HAMAP-Rule:MF_00017]
+
[https://www.uniprot.org/uniprot/RECR_CALS4 RECR_CALS4] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.[HAMAP-Rule:MF_00017]
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
RecR is an important recombination mediator protein in the RecFOR pathway. RecR together with RecO and RecF facilitates RecA nucleoprotein filament formation and homologous pairing. Structural and biochemical studies of Thermoanaerobacter tengcongensis RecR (TTERecR) and its series mutants revealed that TTERecR uses the N-N dimer as a basic functional unit to interact with TTERecO monomer. Two TTERecR N-N dimers form a ring-shaped tetramer via an interaction between their C-terminal regions. The tetramer is a result of crystallization only. Hydrophobic interactions between the entire helix-hairpin-helix domains within the N-terminal regions of two TTERecR monomers are necessary for formation of a RecR functional N-N dimer. The TTERecR N-N dimer conformation also affects formation of a hydrophobic patch, which creates a binding site for TTERecO in the TTERecR Toprim domain. In addition, we demonstrate that TTERecR does not bind single-stranded DNA (ssDNA) and binds double-stranded DNA very weakly, whereas TTERecOR complex can stably bind DNA, with a higher affinity for ssDNA than double-stranded DNA. Based on these results, we propose an interaction model for the RecOR:ssDNA complex.
+
-
 
+
-
RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA.,Tang Q, Gao P, Liu YP, Gao A, An XM, Liu S, Yan XX, Liang DC Nucleic Acids Res. 2012 Nov 1;40(21):11115-25. doi: 10.1093/nar/gks889. Epub 2012, Sep 27. PMID:23019218<ref>PMID:23019218</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3vdp" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cals4]]
+
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Liang, D C]]
+
[[Category: Liang DC]]
-
[[Category: Tang, Q]]
+
[[Category: Tang Q]]
-
[[Category: Yan, X X]]
+
[[Category: Yan XX]]
-
[[Category: Dna binding]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Recombination]]
+
-
[[Category: Zinc finger]]
+

Current revision

Structure and biochemical studies of the recombination mediator protein RecR in RecFOR pathway

PDB ID 3vdp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vdp"
Personal tools