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1hsw

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[[Image:1hsw.gif|left|200px]]
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{{Seed}}
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[[Image:1hsw.png|left|200px]]
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{{STRUCTURE_1hsw| PDB=1hsw | SCENE= }}
{{STRUCTURE_1hsw| PDB=1hsw | SCENE= }}
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'''LYSOZYME (MUCOPEPTIDE N-ACETYLMURAMYL HYDROLASE)'''
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===LYSOZYME (MUCOPEPTIDE N-ACETYLMURAMYL HYDROLASE)===
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==Overview==
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The structures of orthorhombic lysozyme grown at basic pH and its low-humidity variant have been solved and refined at 1.9 and 2.0 A resolution, respectively. A comparison of the native structure with those of crystals grown at acidic pH does not show any systematic pH-dependent difference in the molecular geometry. The conformations, mutual orientation and interactions of the catalytic residues Glu35 and Asp52 also remain unchanged. However, comparison between the native and low-humidity forms in the orthorhombic form show that the changes in molecular geometry which accompany the water-mediated transformation to the low-humidity form are more pronounced in the C-terminal residues than in the other regions of the molecule. During the transformation from the native to the low-humidity form, the locations of only about half the water molecules in the hydration shell remain unchanged, but the hydration shell as a whole moves along with the protein molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 10089340 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10089340}}
==About this Structure==
==About this Structure==
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[[Category: Glycosidase]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:11:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:37:54 2008''

Revision as of 05:37, 1 July 2008

Image:1hsw.png

Template:STRUCTURE 1hsw

LYSOZYME (MUCOPEPTIDE N-ACETYLMURAMYL HYDROLASE)

Template:ABSTRACT PUBMED 10089340

About this Structure

1HSW is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structures of orthorhombic lysozyme grown at basic pH and its low-humidity variant., Sukumar N, Biswal BK, Vijayan M, Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):934-7. PMID:10089340

Page seeded by OCA on Tue Jul 1 08:37:54 2008

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