1hu9

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{{Seed}}
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{{STRUCTURE_1hu9| PDB=1hu9 | SCENE= }}
{{STRUCTURE_1hu9| PDB=1hu9 | SCENE= }}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL'''
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===LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL===
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==Overview==
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Scientific research provides documented evidence that fatty acid metabolites have profound impact on carcinogenesis. Intervention into dioxygenase pathways might therefore effect development, metastasis and progression of many types of cancers. This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase in a non-competitive manner. Trapped in that complex, it undergoes photodegradation in the X-rays, but utilizes enzyme catalytic ability to form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our observations about this radiation and time-dependent inhibition add new information to the role that curcumin might play in cancer prevention and treatment.
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(as it appears on PubMed at http://www.pubmed.gov), where 12792803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12792803}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Purple lipoxygenase]]
[[Category: Purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:14:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:41:02 2008''

Revision as of 05:41, 1 July 2008

Image:1hu9.png

Template:STRUCTURE 1hu9

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL

Template:ABSTRACT PUBMED 12792803

About this Structure

1HU9 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Structure of curcumin in complex with lipoxygenase and its significance in cancer., Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J, Int J Mol Med. 2003 Jul;12(1):17-24. PMID:12792803

Page seeded by OCA on Tue Jul 1 08:41:02 2008

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