3wce

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Current revision (13:03, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wce' size='340' side='right'caption='[[3wce]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='3wce' size='340' side='right'caption='[[3wce]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wce]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wce]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ER4:(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3-YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL'>ER4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wca|3wca]], [[3wc9|3wc9]], [[3wcb|3wcb]], [[3wcc|3wcc]], [[3wcd|3wcd]], [[3wcf|3wcf]], [[3wcg|3wcg]], [[3wch|3wch]], [[3wci|3wci]], [[3wcj|3wcj]], [[3wcl|3wcl]], [[3wcm|3wcm]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ER4:(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3-YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL'>ER4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053508369.20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wce OCA], [https://pdbe.org/3wce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wce RCSB], [https://www.ebi.ac.uk/pdbsum/3wce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wce ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wce OCA], [https://pdbe.org/3wce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wce RCSB], [https://www.ebi.ac.uk/pdbsum/3wce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wce ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4CWB4_TRYCC Q4CWB4_TRYCC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Squalene synthase]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Trycc]]
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[[Category: Chan HC]]
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[[Category: Chan, H C]]
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[[Category: Chen CC]]
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[[Category: Chen, C C]]
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[[Category: Guo RT]]
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[[Category: Guo, R T]]
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[[Category: Huang CH]]
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[[Category: Huang, C H]]
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[[Category: Ko TP]]
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[[Category: Ko, T P]]
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[[Category: Li Q]]
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[[Category: Li, Q]]
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[[Category: Ren F]]
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[[Category: Ren, F]]
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[[Category: Shang N]]
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[[Category: Shang, N]]
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[[Category: Zheng Y]]
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[[Category: Zheng, Y]]
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[[Category: Zhu Z]]
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[[Category: Zhu, Z]]
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[[Category: Drug discovery]]
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[[Category: Er-119884]]
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[[Category: Isoprenoid]]
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[[Category: Transferase]]
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[[Category: Trypanosoma cruzi squalene synthase]]
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Current revision

The complex structure of TcSQS with ligand, ER119884

PDB ID 3wce

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