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| | == Structural highlights == | | == Structural highlights == |
| | <table><tr><td colspan='2'>[[3wea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_japonicus Camponotus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEA FirstGlance]. <br> | | <table><tr><td colspan='2'>[[3wea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_japonicus Camponotus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEA FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3web|3web]]</div></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CjapNPC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=84547 Camponotus japonicus])</td></tr>
| + | |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wea OCA], [https://pdbe.org/3wea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wea RCSB], [https://www.ebi.ac.uk/pdbsum/3wea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wea ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wea OCA], [https://pdbe.org/3wea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wea RCSB], [https://www.ebi.ac.uk/pdbsum/3wea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wea ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/W5JXD9_9HYME W5JXD9_9HYME] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | [[Category: Camponotus japonicus]] | | [[Category: Camponotus japonicus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Fujimoto, Z]] | + | [[Category: Fujimoto Z]] |
| - | [[Category: Ishida, Y]] | + | [[Category: Ishida Y]] |
| - | [[Category: Tsuchiya, W]] | + | [[Category: Tsuchiya W]] |
| - | [[Category: Yamazaki, T]] | + | [[Category: Yamazaki T]] |
| - | [[Category: Carrier protein]]
| + | |
| - | [[Category: Immunoglobulin-like beta-sandwich fold]]
| + | |
| - | [[Category: Lipid binding protein]]
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| Structural highlights
Function
W5JXD9_9HYME
Publication Abstract from PubMed
Ants are eusocial insects that are found in most regions of the world. Within its caste, worker ants are responsible for various tasks that are required for colony maintenance. In their chemical communication, alpha-helical carrier proteins, odorant-binding proteins, and chemosensory proteins, which accumulate in the sensillum lymph in the antennae, play essential roles in transferring hydrophobic semiochemicals to chemosensory receptors. It has been hypothesized that semiochemicals are recognized by alpha-helical carrier proteins. The number of these proteins, however, is not sufficient to interact with a large number of semiochemicals estimated from chemosensory receptor genes. Here we shed light on this conundrum by identifying a Niemann-Pick type C2 (NPC2) protein from the antenna of the worker Japanese carpenter ant, Camponotus japonicus (CjapNPC2). CjapNPC2 accumulated in the sensillum cavity in the basiconic sensillum. The ligand-binding pocket of CjapNPC2 was composed of a flexible beta-structure that allowed it to bind to a wide range of potential semiochemicals. Some of the semiochemicals elicited electrophysiolgical responses in the worker antenna. In vertebrates, NPC2 acts as an essential carrier protein for cholesterol from late endosomes and lysosomes to other cellular organelles. However, the ants have evolved an NPC2 with a malleable ligand-binding pocket as a moderately selective carrier protein in the sensillum cavity of the basiconic sensillum. CjapNPC2 might be able to deliver various hydrophobic semiochemicals to chemosensory receptor neurons and plays crucial roles in chemical communication required to perform the worker ant tasks.
Niemann-Pick type C2 protein mediating chemical communication in the worker ant.,Ishida Y, Tsuchiya W, Fujii T, Fujimoto Z, Miyazawa M, Ishibashi J, Matsuyama S, Ishikawa Y, Yamazaki T Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3847-52. doi:, 10.1073/pnas.1323928111. Epub 2014 Feb 24. PMID:24567405[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ishida Y, Tsuchiya W, Fujii T, Fujimoto Z, Miyazawa M, Ishibashi J, Matsuyama S, Ishikawa Y, Yamazaki T. Niemann-Pick type C2 protein mediating chemical communication in the worker ant. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3847-52. doi:, 10.1073/pnas.1323928111. Epub 2014 Feb 24. PMID:24567405 doi:http://dx.doi.org/10.1073/pnas.1323928111
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