3wj9

From Proteopedia

(Difference between revisions)

Revision as of 04:58, 25 August 2022

Crystal structure of the eukaryotic initiation factor

Structural highlights

3wj9 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[EIF2A_SCHPO] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins (By similarity).

Publication Abstract from PubMed

The eukaryotic translation initiation factor 2A (eIF2A) was identified as a factor that stimulates the binding of methionylated initiator tRNA (Met-tRNA i Met ) to the 40S ribosomal subunit, but its physiological role remains poorly defined. Recently, eIF2A was shown to be involved in unconventional translation initiation from CUG codons and in viral protein synthesis under stress conditions where eIF2 is inactivated. We determined the crystal structure of the WD-repeat domain of Schizosaccharomyces pombe eIF2A at 2.5 A resolution. The structure adopts a novel nine-bladed beta-propeller fold. In contrast to the usual beta-propeller proteins, the central channel of the molecule has the narrower opening on the bottom of the protein and the wider opening on the top. Highly conserved residues are concentrated in the positively-charged top face, suggesting the importance of this face for interactions with nucleic acids or other initiation factors.

Crystal structure of the eukaryotic translation initiation factor 2A from Schizosaccharomyces pombe.,Kashiwagi K, Ito T, Yokoyama S J Struct Funct Genomics. 2014 Feb 26. PMID:24569939^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kashiwagi K, Ito T, Yokoyama S. Crystal structure of the eukaryotic translation initiation factor 2A from Schizosaccharomyces pombe. J Struct Funct Genomics. 2014 Feb 26. PMID:24569939 doi:http://dx.doi.org/10.1007/s10969-014-9177-y

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3wj9"

@@ Line 3: / Line 3: @@
 <StructureSection load='3wj9' size='340' side='right'caption='[[3wj9]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3wj9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WJ9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3wj9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WJ9 FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPBC4B4.04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wj9 OCA], [https://pdbe.org/3wj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wj9 ProSAT]</span></td></tr>
 </table>
@@ Line 26: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Fission yeast]]
 [[Category: Large Structures]]
 [[Category: Ito, T]]

3wj9

From Proteopedia

Revision as of 04:58, 25 August 2022

Crystal structure of the eukaryotic initiation factor

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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