3wo5

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Current revision (13:18, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wo5' size='340' side='right'caption='[[3wo5]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='3wo5' size='340' side='right'caption='[[3wo5]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WO5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ano|3ano]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT2688, Rv2613c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ATP_adenylyltransferase ATP adenylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.53 2.7.7.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo5 OCA], [https://pdbe.org/3wo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo5 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wo5 OCA], [https://pdbe.org/3wo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wo5 RCSB], [https://www.ebi.ac.uk/pdbsum/3wo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wo5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU]] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
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[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ATP adenylyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arakawa, Y]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mori, S]]
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[[Category: Arakawa Y]]
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[[Category: Shibayama, K]]
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[[Category: Mori S]]
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[[Category: Wachino, J]]
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[[Category: Shibayama K]]
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[[Category: Diadenosine polyphosphate]]
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[[Category: Wachino J]]
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[[Category: Hit motif]]
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[[Category: Mycobacterium]]
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[[Category: Phosphorylase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of S147Q of Rv2613c from Mycobacterium tuberculosis

PDB ID 3wo5

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