Sandbox Reserved 1730
From Proteopedia
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== Function == | == Function == | ||
| - | + | Lysozyme binds to the membrane of bacterial cells and catalyzes the breakdown of those membranes killing the cell. The carbohydrates forming the membranes of the bacteria cells are what keep the cell together and functioning. When lysozyme binds to these membranes it catalyzes the reaction between the membrane and water, breaking the bonds between the carbohydrates and causing the membrane to fall apart. The positive charge of lysozyme is what draws it to the negative charge of the bacterial membrane. | |
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== Relevance == | == Relevance == | ||
| + | Lysozyme (muramidase) is an enzyme that can be found in many biological settings. The enzyme is located in saliva, tears, mucous, and human milk. Lysozyme is also found in large concentrations in egg whites from hens. Lysozyme is stable in typical conditions, thus there is a lot of research and information behind the function and structure of the enzyme. | ||
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| + | Lysozyme serves a crucial role in our immune system due to its anti-bacterial properties. The enzyme breaks down the cell membranes of bacterial cells. Lysozyme in a single chain alkaline protein with 129 amino acid residues and four disulfide bonds. It catalyzes the breakdown of β-1,4-glycosidic bonds in the cell membrane of bacterial cells. Lysozyme is also known to have antiviral, antitumor, and anti-inflammatory properties. | ||
== Structural highlights == | == Structural highlights == | ||
| + | Lysozyme is an enzyme with 129 amino acids and four disulfide bridges. The structure of Lysozyme has two major motifs, those being alpha helices and beta strands. Lysozyme had a total of four alpha helices and five beta strands. These two motifs are regularly found in different innate immune system responses. The helices are connected with a loop, with either 2 or 3 beta strands attached to them. | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 19:50, 28 October 2022
| This Sandbox is Reserved from August 30, 2022 through May 31, 2023 for use in the course Biochemistry I taught by Kimberly Lane at the Radford University, Radford, VA, USA. This reservation includes Sandbox Reserved 1730 through Sandbox Reserved 1749. |
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
