7r1d
From Proteopedia
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| - | ==== | + | ==Structure of MuvB complex== |
| - | <StructureSection load='7r1d' size='340' side='right'caption='[[7r1d]]' scene=''> | + | <StructureSection load='7r1d' size='340' side='right'caption='[[7r1d]], [[Resolution|resolution]] 3.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r1d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R1D FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r1d OCA], [https://pdbe.org/7r1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r1d RCSB], [https://www.ebi.ac.uk/pdbsum/7r1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r1d ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r1d OCA], [https://pdbe.org/7r1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r1d RCSB], [https://www.ebi.ac.uk/pdbsum/7r1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r1d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LIN9_HUMAN LIN9_HUMAN]] Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<ref>PMID:15538385</ref> <ref>PMID:16730350</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of protein complexes in a cell cycle-specific manner. Complexes of MuvB with the transcription factors B-MYB and FOXM1 activate mitotic genes during cell proliferation. The mechanisms of transcriptional regulation by these complexes are still poorly characterised. Here, we combine biochemical analysis and in vitro reconstitution, with structural analysis by cryo-electron microscopy and cross-linking mass spectrometry, to functionally examine these complexes. We find that the MuvB:B-MYB complex binds and remodels nucleosomes, thereby exposing nucleosomal DNA. This remodelling activity is supported by B-MYB which directly binds the remodelled DNA. Given the remodelling activity on the nucleosome, we propose that the MuvB:B-MYB complex functions as a pioneer transcription factor complex. In this work, we rationalise prior biochemical and cellular studies and provide a molecular framework of interactions on a protein complex that is key for cell cycle regulation. | ||
| + | |||
| + | Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.,Koliopoulos MG, Muhammad R, Roumeliotis TI, Beuron F, Choudhary JS, Alfieri C Nat Commun. 2022 Aug 29;13(1):5075. doi: 10.1038/s41467-022-32798-9. PMID:36038598<ref>PMID:36038598</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7r1d" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Alfieri C]] |
| + | [[Category: Koliopoulos MG]] | ||
Revision as of 07:02, 14 September 2022
Structure of MuvB complex
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