2xpb

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Current revision (10:36, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2xpb' size='340' side='right'caption='[[2xpb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2xpb' size='340' side='right'caption='[[2xpb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4GE:5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>4GE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f8a|1f8a]], [[1i8g|1i8g]], [[1pin|1pin]], [[2xp3|2xp3]], [[2xp8|2xp8]], [[2xp5|2xp5]], [[1nmv|1nmv]], [[2xp9|2xp9]], [[1nmw|1nmw]], [[1zcn|1zcn]], [[2xp4|2xp4]], [[2xp7|2xp7]], [[2f21|2f21]], [[2xp6|2xp6]], [[1i8h|1i8h]], [[2xpa|2xpa]], [[1i6c|1i6c]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=4GE:5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC+ACID'>4GE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpb OCA], [https://pdbe.org/2xpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpb RCSB], [https://www.ebi.ac.uk/pdbsum/2xpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpb OCA], [https://pdbe.org/2xpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpb RCSB], [https://www.ebi.ac.uk/pdbsum/2xpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Baker L]]
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[[Category: Baker, L]]
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[[Category: Bryant CJ]]
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[[Category: Bryant, C J]]
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[[Category: Davis BE]]
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[[Category: Davis, B E]]
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[[Category: Dokurno P]]
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[[Category: Dokurno, P]]
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[[Category: Fromont C]]
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[[Category: Fromont, C]]
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[[Category: Matossova N]]
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[[Category: Matossova, N]]
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[[Category: Moore JD]]
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[[Category: Moore, J D]]
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[[Category: Murray JB]]
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[[Category: Murray, J B]]
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[[Category: Northfield CJ]]
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[[Category: Northfield, C J]]
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[[Category: Nunns C]]
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[[Category: Nunns, C]]
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[[Category: Oldfield V]]
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[[Category: Oldfield, V]]
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[[Category: Potter A]]
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[[Category: Potter, A]]
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[[Category: Ray S]]
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[[Category: Ray, S]]
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[[Category: Richardson CM]]
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[[Category: Richardson, C M]]
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[[Category: Robinson D]]
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[[Category: Robinson, D]]
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[[Category: Scrace SF]]
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[[Category: Scrace, S F]]
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[[Category: Surgenor AE]]
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[[Category: Surgenor, A E]]
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[[Category: Cell cycle]]
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[[Category: Isomerase]]
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[[Category: Oncogenic transformation]]
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[[Category: Proline directed kinase]]
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Current revision

DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION

PDB ID 2xpb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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