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3wso

From Proteopedia

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Current revision (13:26, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wso' size='340' side='right'caption='[[3wso]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3wso' size='340' side='right'caption='[[3wso]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wso]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSO FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e31|2e31]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FBXO44, FBG3, FBX30, FBX44, FBX6A, FBXO6A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SKP1, EMC19, OCP2, SKP1A, TCEB1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wso OCA], [https://pdbe.org/3wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wso RCSB], [https://www.ebi.ac.uk/pdbsum/3wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wso ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wso OCA], [https://pdbe.org/3wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wso RCSB], [https://www.ebi.ac.uk/pdbsum/3wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wso ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FBX44_HUMAN FBX44_HUMAN]] Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. [[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN]] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref>
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[https://www.uniprot.org/uniprot/FBX44_HUMAN FBX44_HUMAN] Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Iwai, K]]
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[[Category: Iwai K]]
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[[Category: Kumanomidou, T]]
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[[Category: Kumanomidou T]]
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[[Category: Mizushima, T]]
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[[Category: Mizushima T]]
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[[Category: Murakami, A]]
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[[Category: Murakami A]]
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[[Category: Nakagawa, T]]
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[[Category: Nakagawa T]]
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[[Category: Nishio, K]]
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[[Category: Nishio K]]
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[[Category: Suzuki, A]]
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[[Category: Suzuki A]]
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[[Category: Takagi, K]]
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[[Category: Takagi K]]
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[[Category: Tanaka, K]]
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[[Category: Tanaka K]]
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[[Category: Tokunaga, F]]
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[[Category: Tokunaga F]]
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[[Category: Yamane, T]]
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[[Category: Yamane T]]
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[[Category: Yoshida, Y]]
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[[Category: Yoshida Y]]
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[[Category: F-box protein]]
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[[Category: Ligase]]
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[[Category: Scf ubiquitin ligase]]
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[[Category: Skp1]]
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Current revision

Crystal structure of the Skp1-FBG3 complex

PDB ID 3wso

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OCA

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