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3zbo

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A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures

Structural highlights

3zbo is a 2 chain structure with sequence from Bacillus cereus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.58Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q81BA8_BACCR

Publication Abstract from PubMed

The recently discovered HEAT-like repeat (HLR) DNA glycosylase superfamily is widely distributed in all domains of life. The present bioinformatics and phylogenetic analysis shows that HLR DNA glycosylase superfamily members in the genus Bacillus form three subfamilies: AlkC, AlkD and AlkF/AlkG. The crystal structure of AlkF shows structural similarity with the DNA glycosylases AlkC and AlkD, however neither AlkF nor AlkG display any DNA glycosylase activity. Instead, both proteins have affinity to branched DNA structures such as three-way and Holliday junctions. A unique beta-hairpin in the AlkF/AlkG subfamily is most likely inserted into the DNA major groove, and could be a structural determinant regulating DNA substrate affinity. We conclude that AlkF and AlkG represent a new family of HLR proteins with affinity for branched DNA structures.

A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures.,Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolsto AB, Bjoras M J Struct Biol. 2013 Apr 25. pii: S1047-8477(13)00107-X. doi:, 10.1016/j.jsb.2013.04.007. PMID:23623903^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolsto AB, Bjoras M. A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures. J Struct Biol. 2013 Apr 25. pii: S1047-8477(13)00107-X. doi:, 10.1016/j.jsb.2013.04.007. PMID:23623903 doi:10.1016/j.jsb.2013.04.007

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zbo"

@@ Line 3: / Line 3: @@
 <StructureSection load='3zbo' size='340' side='right'caption='[[3zbo]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3zbo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZBO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3zbo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZBO FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zbo OCA], [https://pdbe.org/3zbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zbo RCSB], [https://www.ebi.ac.uk/pdbsum/3zbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zbo ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q81BA8_BACCR Q81BA8_BACCR]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 14579]]
+[[Category: Bacillus cereus]]
 [[Category: Large Structures]]
-[[Category: Alseth, I]]
+[[Category: Alseth I]]
-[[Category: Backe, P H]]
+[[Category: Backe PH]]
-[[Category: Bjoras, M]]
+[[Category: Bjoras M]]
-[[Category: Dalhus, B]]
+[[Category: Dalhus B]]
-[[Category: Fagerlund, A]]
+[[Category: Fagerlund A]]
-[[Category: Kolsto, A B]]
+[[Category: Kolsto A-B]]
-[[Category: Laerdahl, J K]]
+[[Category: Laerdahl JK]]
-[[Category: Okstad, O A]]
+[[Category: Okstad OA]]
-[[Category: Rognes, T]]
+[[Category: Rognes T]]
-[[Category: Simm, R]]
+[[Category: Simm R]]
-[[Category: Alkc]]
-[[Category: Alkd]]
-[[Category: Base excision repair]]
-[[Category: Dna damage]]
-[[Category: Holliday junction]]
-[[Category: Unknown function]]

3zbo

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Current revision

A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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