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3zfh

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Current revision (11:00, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zfh' size='340' side='right'caption='[[3zfh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3zfh' size='340' side='right'caption='[[3zfh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZFH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZFH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zfh OCA], [https://pdbe.org/3zfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zfh RCSB], [https://www.ebi.ac.uk/pdbsum/3zfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zfh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zfh OCA], [https://pdbe.org/3zfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zfh RCSB], [https://www.ebi.ac.uk/pdbsum/3zfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zfh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q9HXM5_PSEAE Q9HXM5_PSEAE]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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[https://www.uniprot.org/uniprot/Q9HXM5_PSEAE Q9HXM5_PSEAE] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: IMP dehydrogenase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseae]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Hunter, W N]]
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[[Category: Hunter WN]]
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[[Category: Owen, R]]
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[[Category: Owen R]]
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[[Category: Rao, V A]]
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[[Category: Rao VA]]
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[[Category: Shepherd, S M]]
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[[Category: Shepherd SM]]
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[[Category: Guanine nucleotide biosynthesis]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase

PDB ID 3zfh

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