1hx8

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{{STRUCTURE_1hx8| PDB=1hx8 | SCENE= }}
{{STRUCTURE_1hx8| PDB=1hx8 | SCENE= }}
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'''CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF DROSOPHILA AP180'''
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===CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF DROSOPHILA AP180===
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==Overview==
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Clathrin-mediated endocytosis plays a major role in retrieving synaptic vesicles from the plasma membrane following exocytosis. This endocytic process requires AP180 (or a homolog), which promotes the assembly and restricts the size of clathrin-coated vesicles. The highly conserved 33 kDa amino-terminal domain of AP180 plays a critical role in binding to phosphoinositides and in regulating the clathrin assembly activity of AP180. The crystal structure of the amino-terminal domain reported herein reveals a novel fold consisting of a large double layer of sheets of ten alpha helices and a unique site for binding phosphoinositides. The finding that the clathrin-box motif is mostly buried and lies in a helix indicates a different site and mechanism for binding of the domain to clathrins than previously assumed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11239400 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11239400}}
==About this Structure==
==About this Structure==
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[[Category: Alpha helices repeat]]
[[Category: Alpha helices repeat]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:19:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:03:44 2008''

Revision as of 07:03, 1 July 2008

Image:1hx8.png

Template:STRUCTURE 1hx8

CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF DROSOPHILA AP180

Template:ABSTRACT PUBMED 11239400

About this Structure

1HX8 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis., Mao Y, Chen J, Maynard JA, Zhang B, Quiocho FA, Cell. 2001 Feb 9;104(3):433-40. PMID:11239400

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