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3zhp

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Current revision (11:02, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zhp' size='340' side='right'caption='[[3zhp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3zhp' size='340' side='right'caption='[[3zhp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zhp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zhp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZHP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhp OCA], [https://pdbe.org/3zhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zhp RCSB], [https://www.ebi.ac.uk/pdbsum/3zhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zhp OCA], [https://pdbe.org/3zhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zhp RCSB], [https://www.ebi.ac.uk/pdbsum/3zhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CB39L_HUMAN CB39L_HUMAN]] Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). [[https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN]] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>
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[https://www.uniprot.org/uniprot/CB39L_HUMAN CB39L_HUMAN] Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Alessi DR]]
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[[Category: Alessi, D R]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Chaikaud A]]
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[[Category: Chaikaud, A]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Elkins JM]]
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[[Category: Edwards, A]]
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[[Category: Knapp S]]
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[[Category: Elkins, J M]]
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[[Category: Krojer T]]
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[[Category: Knapp, S]]
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[[Category: Mehellou Y]]
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[[Category: Krojer, T]]
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[[Category: Szklarz M]]
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[[Category: Mehellou, Y]]
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[[Category: Von Delft F]]
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[[Category: Szklarz, M]]
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[[Category: Cell cycle]]
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[[Category: Mo25]]
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Current revision

Human MST3 (STK24) in complex with MO25beta

PDB ID 3zhp

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