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3zj6

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Current revision (11:02, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zj6' size='340' side='right'caption='[[3zj6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3zj6' size='340' side='right'caption='[[3zj6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VM2:(1R,2S,3S,4R,5R)-4-(CYCLOHEXYLMETHYLAMINO)-5-(HYDROXYMETHYL)CYCLOPENTANE-1,2,3-TRIOL'>VM2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zj7|3zj7]], [[3zj8|3zj8]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VM2:(1R,2S,3S,4R,5R)-4-(CYCLOHEXYLMETHYLAMINO)-5-(HYDROXYMETHYL)CYCLOPENTANE-1,2,3-TRIOL'>VM2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Raucaffricine_beta-glucosidase Raucaffricine beta-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.125 3.2.1.125] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zj6 OCA], [https://pdbe.org/3zj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zj6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zj6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zj6 OCA], [https://pdbe.org/3zj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zj6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zj6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RG1_RAUSE RG1_RAUSE] Glucosidase specifically involved in alkaloid biosynthesis leading to the accumulation of several alkaloids, including ajmaline, an important plant-derived pharmaceutical used in the treatment of heart disorders.<ref>PMID:10975500</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ophioxylon serpentinum]]
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[[Category: Rauvolfia serpentina]]
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[[Category: Raucaffricine beta-glucosidase]]
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[[Category: Castiglia A]]
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[[Category: Castiglia, A]]
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[[Category: Jaeger V]]
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[[Category: Jaeger, V]]
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[[Category: Lin H]]
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[[Category: Lin, H]]
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[[Category: Panjikar S]]
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[[Category: Panjikar, S]]
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[[Category: Rajendran C]]
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[[Category: Rajendran, C]]
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[[Category: Ruppert M]]
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[[Category: Ruppert, M]]
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[[Category: Schuebel H]]
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[[Category: Schuebel, H]]
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[[Category: Stoeckigt J]]
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[[Category: Stoeckigt, J]]
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[[Category: Wang M]]
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[[Category: Wang, M]]
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[[Category: Warzecha H]]
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[[Category: Warzecha, H]]
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[[Category: Xia L]]
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[[Category: Xia, L]]
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[[Category: Alkaloid]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Rg]]
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Current revision

Crystal of Raucaffricine Glucosidase in complex with inhibitor

PDB ID 3zj6

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OCA

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