8e11
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mouse DNA polymerase Beta (PolB) mutant== | |
| - | + | <StructureSection load='8e11' size='340' side='right'caption='[[8e11]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E11 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e11 OCA], [https://pdbe.org/8e11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e11 RCSB], [https://www.ebi.ac.uk/pdbsum/8e11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e11 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPOLB_MOUSE DPOLB_MOUSE] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Prakash A]] | ||
| + | [[Category: Sharma N]] | ||
| + | [[Category: Thompson MK]] | ||
Revision as of 11:21, 1 February 2023
Structure of mouse DNA polymerase Beta (PolB) mutant
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