7pcv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of RBM5 RRM1-zinc finger== | ==Crystal structure of RBM5 RRM1-zinc finger== | ||
| - | <StructureSection load='7pcv' size='340' side='right'caption='[[7pcv]]' scene=''> | + | <StructureSection load='7pcv' size='340' side='right'caption='[[7pcv]], [[Resolution|resolution]] 2.42Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7pcv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcv OCA], [https://pdbe.org/7pcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcv RCSB], [https://www.ebi.ac.uk/pdbsum/7pcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcv ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcv OCA], [https://pdbe.org/7pcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcv RCSB], [https://www.ebi.ac.uk/pdbsum/7pcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBM5_HUMAN RBM5_HUMAN] Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.<ref>PMID:10949932</ref> <ref>PMID:12207175</ref> <ref>PMID:12581154</ref> <ref>PMID:15192330</ref> <ref>PMID:16585163</ref> <ref>PMID:18851835</ref> <ref>PMID:18840686</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jagtap PKA]] | [[Category: Jagtap PKA]] | ||
[[Category: Sattler M]] | [[Category: Sattler M]] | ||
[[Category: Soni K]] | [[Category: Soni K]] | ||
Current revision
Crystal structure of RBM5 RRM1-zinc finger
| |||||||||||
