7vm1
From Proteopedia
(Difference between revisions)
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==Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin== | ==Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin== | ||
| - | <StructureSection load='7vm1' size='340' side='right'caption='[[7vm1]]' scene=''> | + | <StructureSection load='7vm1' size='340' side='right'caption='[[7vm1]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VM1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vm1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VM1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vm1 OCA], [https://pdbe.org/7vm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7vm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vm1 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7OH:Fe-Tetra(4-pyridyl)porphyrin'>7OH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vm1 OCA], [https://pdbe.org/7vm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7vm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vm1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene. | ||
| + | |||
| + | Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7vm1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
[[Category: Sakakibara E]] | [[Category: Sakakibara E]] | ||
[[Category: Shisaka Y]] | [[Category: Shisaka Y]] | ||
Current revision
Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin
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