8dgg

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==Structure of glycosylated LAG-3 homodimer==
==Structure of glycosylated LAG-3 homodimer==
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<StructureSection load='8dgg' size='340' side='right'caption='[[8dgg]]' scene=''>
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<StructureSection load='8dgg' size='340' side='right'caption='[[8dgg]], [[Resolution|resolution]] 3.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[8dgg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGG FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgg OCA], [https://pdbe.org/8dgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgg RCSB], [https://www.ebi.ac.uk/pdbsum/8dgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgg ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgg OCA], [https://pdbe.org/8dgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgg RCSB], [https://www.ebi.ac.uk/pdbsum/8dgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgg ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/LAG3_MOUSE LAG3_MOUSE]] Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966). Delivers inhibitory signals upon binding to ligands, such as FGL1 (PubMed:30580966). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (PubMed:21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed:15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed:19201841). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:12209638, PubMed:12421911, PubMed:15634887).<ref>PMID:12209638</ref> <ref>PMID:12421911</ref> <ref>PMID:12672063</ref> <ref>PMID:15100286</ref> <ref>PMID:15485628</ref> <ref>PMID:15634887</ref> <ref>PMID:19201841</ref> <ref>PMID:21300912</ref> <ref>PMID:30580966</ref> May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.<ref>PMID:11937541</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cochran JR]]
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[[Category: Chan, K W]]
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[[Category: Mathews II]]
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[[Category: Cochran, J R]]
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[[Category: Silberstein JL]]
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[[Category: Du, J]]
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[[Category: Fernandez, D]]
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[[Category: Frank, J A]]
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[[Category: Kong, X P]]
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[[Category: Mathews, I I]]
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[[Category: Silberstein, J L]]
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[[Category: Wang, J]]
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[[Category: Glycosylation]]
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[[Category: Homodimer]]
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[[Category: Immune checkpoint receptor]]
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[[Category: Immune system]]

Revision as of 06:46, 31 August 2022

Structure of glycosylated LAG-3 homodimer

PDB ID 8dgg

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