7win

From Proteopedia

(Difference between revisions)

Revision as of 17:41, 29 November 2023

Crystal structure of BAZ2B TAM domain

Structural highlights

7win is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.95Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BAZ2B_HUMAN May play a role in transcriptional regulation interacting with ISWI.

Publication Abstract from PubMed

BAZ2B is a regulatory subunit of the ISWI (Imitation Switch) remodeling complex and engages in nucleosome remodeling. Loss-of-function and haploinsufficiency of BAZ2B are associated with different diseases. BAZ2B is a large multidomain protein. In addition to the epigenetic reader domains plant homeodomain (PHD) and bromodomain (BRD), BAZ2B also has a Tip5/ARBP/MBD (TAM) domain. Sequence alignment revealed that the TAM domains of BAZ2A and BAZ2B share 53% sequence identity. How the BAZ2A TAM domain bound with DNA has been characterized recently, however, the DNA binding ability and methylation preference, as well as the structural basis of the BAZ2B TAM domain are not studied yet. In this study, we measured the DNA binding affinity of the TAM domain of BAZ2B, and also determined its apo crystal structure. We found that the TAM domains of BAZ2A and BAZ2B adopt almost the same fold, and like BAZ2A, the BAZ2B TAM domain also binds to dsDNA without methyl-cytosine preference, implying that the BAZ2B TAM domain might recognize DNA in a similar binding mode to that of the BAZ2A TAM domain. These results provide clues for the biological function study of BAZ2B in the future.

Crystal structure of the BAZ2B TAM domain.,Feng Y, Chen S, Zhou M, Zhang J, Min J, Liu K Heliyon. 2022 Jul 6;8(7):e09873. doi: 10.1016/j.heliyon.2022.e09873. eCollection , 2022 Jul. PMID:35865993^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Feng Y, Chen S, Zhou M, Zhang J, Min J, Liu K. Crystal structure of the BAZ2B TAM domain. Heliyon. 2022 Jul 6;8(7):e09873. doi: 10.1016/j.heliyon.2022.e09873. eCollection , 2022 Jul. PMID:35865993 doi:http://dx.doi.org/10.1016/j.heliyon.2022.e09873

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7win"

Categories: Homo sapiens | Large Structures | Feng YY | Liu K | Min JR

@@ Line 3: / Line 3: @@
 <StructureSection load='7win' size='340' side='right'caption='[[7win]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[7win]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7win]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIN FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7win FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7win OCA], [https://pdbe.org/7win PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7win RCSB], [https://www.ebi.ac.uk/pdbsum/7win PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7win ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7win FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7win OCA], [https://pdbe.org/7win PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7win RCSB], [https://www.ebi.ac.uk/pdbsum/7win PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7win ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/BAZ2B_HUMAN BAZ2B_HUMAN]] May play a role in transcriptional regulation interacting with ISWI.
+[https://www.uniprot.org/uniprot/BAZ2B_HUMAN BAZ2B_HUMAN] May play a role in transcriptional regulation interacting with ISWI.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 18: @@
 </div>
 <div class="pdbe-citations 7win" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Bromodomain adjacent to zinc finger 3D structures|Bromodomain adjacent to zinc finger 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Feng, Y Y]]
+[[Category: Feng YY]]
-[[Category: Liu, K]]
+[[Category: Liu K]]
-[[Category: Min, J R]]
+[[Category: Min JR]]
-[[Category: Baz2b]]
-[[Category: Dna binding protein]]
-[[Category: Tam domain]]

7win

From Proteopedia

Revision as of 17:41, 29 November 2023

Crystal structure of BAZ2B TAM domain

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox