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3zra

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Current revision (10:42, 9 May 2024) (edit) (undo)
 
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<StructureSection load='3zra' size='340' side='right'caption='[[3zra]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3zra' size='340' side='right'caption='[[3zra]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORB:N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c7a|2c7a]], [[2w8y|2w8y]], [[3zr7|3zr7]], [[1e3k|1e3k]], [[3zrb|3zrb]], [[1a28|1a28]], [[1zuc|1zuc]], [[1sqn|1sqn]], [[1sr7|1sr7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORB:N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zra OCA], [https://pdbe.org/3zra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zra RCSB], [https://www.ebi.ac.uk/pdbsum/3zra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zra ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zra OCA], [https://pdbe.org/3zra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zra RCSB], [https://www.ebi.ac.uk/pdbsum/3zra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zra ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Azevedo, R]]
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[[Category: Azevedo R]]
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[[Category: Brown, A R]]
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[[Category: Brown AR]]
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[[Category: Dechering, K]]
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[[Category: Dechering K]]
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[[Category: Hamilton, N M]]
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[[Category: Hamilton NM]]
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[[Category: Lam, T Wai]]
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[[Category: Lusher SJ]]
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[[Category: Lusher, S J]]
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[[Category: McGuire R]]
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[[Category: McGuire, R]]
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[[Category: Nimz O]]
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[[Category: Nimz, O]]
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[[Category: Oubrie A]]
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[[Category: Oubrie, A]]
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[[Category: Raaijmakers HCA]]
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[[Category: Raaijmakers, H C.A]]
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[[Category: Vu-Pham D]]
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[[Category: Vlieg, J de]]
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[[Category: Wai Lam T]]
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[[Category: Vu-Pham, D]]
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[[Category: De Vlieg J]]
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[[Category: Hormone receptor]]
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Current revision

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

PDB ID 3zra

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