3zwj
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zwj]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zwj]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWJ FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwj OCA], [https://pdbe.org/3zwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwj RCSB], [https://www.ebi.ac.uk/pdbsum/3zwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwj OCA], [https://pdbe.org/3zwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwj RCSB], [https://www.ebi.ac.uk/pdbsum/3zwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Actinia fragacea]] | [[Category: Actinia fragacea]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bellomioa | + | [[Category: Bellomioa A]] |
| - | [[Category: Gonzalez-Manas | + | [[Category: Gonzalez-Manas JM]] |
| - | [[Category: Guerin | + | [[Category: Guerin DMA]] |
| - | [[Category: Mechaly | + | [[Category: Mechaly AE]] |
| - | [[Category: Morantea | + | [[Category: Morantea K]] |
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Current revision
CRYSTAL STRUCTURE OF THE PORE-FORMING TOXIN FRAC FROM ACTINIA FRAGACEA (Form 3)
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