3zxg

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Current revision (11:15, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zxg' size='340' side='right'caption='[[3zxg]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
<StructureSection load='3zxg' size='340' side='right'caption='[[3zxg]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisfe Eisfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zx7|3zx7]], [[3zxd|3zxd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [https://pdbe.org/3zxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [https://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [https://pdbe.org/3zxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [https://www.ebi.ac.uk/pdbsum/3zxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
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[https://www.uniprot.org/uniprot/TXL_EISFE TXL_EISFE] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Eisfe]]
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[[Category: Eisenia fetida]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abrusci, P]]
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[[Category: Abrusci P]]
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[[Category: Anderluh, G]]
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[[Category: Anderluh G]]
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[[Category: Colibus, L De]]
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[[Category: De Colibus L]]
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[[Category: Gilbert, R J.C]]
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[[Category: Gilbert RJC]]
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[[Category: Hodnik, V]]
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[[Category: Hodnik V]]
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[[Category: Leippe, M]]
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[[Category: Leippe M]]
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[[Category: Morris, K J]]
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[[Category: Morris KJ]]
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[[Category: Plitzko, J]]
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[[Category: Plitzko J]]
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[[Category: Siebert, C A]]
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[[Category: Siebert CA]]
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[[Category: Sonnen, A F.P]]
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[[Category: Sonnen AFP]]
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[[Category: Volpi, E]]
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[[Category: Volpi E]]
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[[Category: Earthworm]]
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[[Category: Pore-forming toxin]]
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[[Category: Toxin]]
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Current revision

lysenin sphingomyelin complex

PDB ID 3zxg

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