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4a6l
From Proteopedia
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<StructureSection load='4a6l' size='340' side='right'caption='[[4a6l]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4a6l' size='340' side='right'caption='[[4a6l]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4a6l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4a6l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P43:1-{3-[1-({5-[(2-FLUOROPHENYL)ETHYNYL]FURAN-2-YL}CARBONYL)PIPERIDIN-4-YL]PHENYL}METHANAMINE'>P43</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6l OCA], [https://pdbe.org/4a6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6l RCSB], [https://www.ebi.ac.uk/pdbsum/4a6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6l OCA], [https://pdbe.org/4a6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6l RCSB], [https://www.ebi.ac.uk/pdbsum/4a6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity). | |
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==See Also== | ==See Also== | ||
*[[Tryptase|Tryptase]] | *[[Tryptase|Tryptase]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Maignan S]] | |
| - | [[Category: Maignan | + | [[Category: Mathieu M]] |
| - | [[Category: Mathieu | + | |
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Current revision
beta-tryptase inhibitor
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