Transcriptional activator
From Proteopedia
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<StructureSection load='1h89' size='350' side='right' caption='Structure of transcriptional activator C-Myb DNA-binding domain (deeppink) complex with DNA, CAAT/enhancer binding protein β (cyan and green) and K+ ion (purple) (PDB entry [[1h89]])' scene='55/553105/Cv/1'> | <StructureSection load='1h89' size='350' side='right' caption='Structure of transcriptional activator C-Myb DNA-binding domain (deeppink) complex with DNA, CAAT/enhancer binding protein β (cyan and green) and K+ ion (purple) (PDB entry [[1h89]])' scene='55/553105/Cv/1'> | ||
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== Function == | == Function == | ||
'''Transcriptional activators''' or '''Transcriptional regulators''' (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD)<ref>PMID:16464826</ref>. '''PrfA''' is an activator of virulence genes in ''Listeria monocytogenes''<ref>PMID:10564496</ref>. See also [[Listeriolysin positive regulatory factor A]]. | '''Transcriptional activators''' or '''Transcriptional regulators''' (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD)<ref>PMID:16464826</ref>. '''PrfA''' is an activator of virulence genes in ''Listeria monocytogenes''<ref>PMID:10564496</ref>. See also [[Listeriolysin positive regulatory factor A]]. | ||
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References
- ↑ Titz B, Thomas S, Rajagopala SV, Chiba T, Ito T, Uetz P. Transcriptional activators in yeast. Nucleic Acids Res. 2006 Feb 7;34(3):955-67. Print 2006. PMID:16464826 doi:http://dx.doi.org/34/3/955
- ↑ Renzoni A, Cossart P, Dramsi S. PrfA, the transcriptional activator of virulence genes, is upregulated during interaction of Listeria monocytogenes with mammalian cells and in eukaryotic cell extracts. Mol Microbiol. 1999 Nov;34(3):552-61. doi: 10.1046/j.1365-2958.1999.01621.x. PMID:10564496 doi:http://dx.doi.org/10.1046/j.1365-2958.1999.01621.x
