8ar0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of TLR2 transmembrane and cytoplasmic juxtamembrane regions== | |
| - | + | <StructureSection load='8ar0' size='340' side='right'caption='[[8ar0]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ar0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar0 OCA], [https://pdbe.org/8ar0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar0 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arseniev AS]] | ||
| + | [[Category: Goncharuk MV]] | ||
| + | [[Category: Goncharuk SA]] | ||
| + | [[Category: Kornilov FD]] | ||
| + | [[Category: Mineev KS]] | ||
| + | [[Category: Shabalkina AV]] | ||
Revision as of 07:20, 22 March 2023
Solution structure of TLR2 transmembrane and cytoplasmic juxtamembrane regions
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