8ar3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions== | |
| - | + | <StructureSection load='8ar3' size='340' side='right'caption='[[8ar3]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ar3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar3 OCA], [https://pdbe.org/8ar3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar3 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TLR9_HUMAN TLR9_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).[UniProtKB:Q9EQU3]<ref>PMID:11564765</ref> <ref>PMID:17932028</ref> <ref>PMID:23857366</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arseniev AS]] | ||
| + | [[Category: Goncharuk MV]] | ||
| + | [[Category: Goncharuk SA]] | ||
| + | [[Category: Kornilov FD]] | ||
| + | [[Category: Mineev KS]] | ||
| + | [[Category: Shabalkina AV]] | ||
Revision as of 07:20, 22 March 2023
Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions
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