8arf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the N-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein Spindly== | |
| - | + | <StructureSection load='8arf' size='340' side='right'caption='[[8arf]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8arf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ARF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ARF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8arf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8arf OCA], [https://pdbe.org/8arf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8arf RCSB], [https://www.ebi.ac.uk/pdbsum/8arf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8arf ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Ahmad | + | [[https://www.uniprot.org/uniprot/SPDLY_HUMAN SPDLY_HUMAN]] Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100).[HAMAP-Rule:MF_03041]<ref>PMID:17576797</ref> <ref>PMID:19468067</ref> <ref>PMID:25035494</ref> <ref>PMID:30258100</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahmad MU]] | ||
| + | [[Category: Perrakis A]] | ||
Revision as of 16:41, 7 September 2022
Crystal structure of the N-terminal parallel dimeric coiled-coil region of the human kinetochore associated protein Spindly
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