This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7lu7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human TDO (hTDO) in complex with NLG919 analog== | ==Human TDO (hTDO) in complex with NLG919 analog== | ||
| - | <StructureSection load='7lu7' size='340' side='right'caption='[[7lu7]]' scene=''> | + | <StructureSection load='7lu7' size='340' side='right'caption='[[7lu7]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LU7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lu7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LU7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lu7 OCA], [https://pdbe.org/7lu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lu7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lu7 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5PK:(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-5~{H}-IMIDAZO[1,5-B]ISOINDOL-5-YL]ETHANOL'>5PK</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZIQ:alpha-methyl-L-tryptophan'>ZIQ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lu7 OCA], [https://pdbe.org/7lu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lu7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lu7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Yeh S-R]] | [[Category: Yeh S-R]] | ||
Current revision
Human TDO (hTDO) in complex with NLG919 analog
| |||||||||||
