1g4k
From Proteopedia
(New page: 200px<br /> <applet load="1g4k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g4k, resolution 2.0Å" /> '''X-ray Structure of a...) |
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| - | [[Image:1g4k.gif|left|200px]]<br /> | + | [[Image:1g4k.gif|left|200px]]<br /><applet load="1g4k" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1g4k" size=" | + | |
caption="1g4k, resolution 2.0Å" /> | caption="1g4k, resolution 2.0Å" /> | ||
'''X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin'''<br /> | '''X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A new class of matrix metalloproteinase (MMP) inhibitors has been | + | A new class of matrix metalloproteinase (MMP) inhibitors has been identified by screening a collection of compounds against stromelysin. The inhibitors, 2,4,6-pyrimidine triones, have proven to be potent inhibitors of gelatinases A and B. An X-ray crystal structure of one representative compound bound to the catalytic domain of stromelysin shows that the compounds bind at the active site and ligand the active-site zinc. The pyrimidine triones mimic substrates in forming hydrogen bonds to key residues in the active site, and provide opportunities for placing appropriately chosen groups into the S1' specificity pocket of MMPS: A number of compounds have been synthesized and assayed against stromelysin, and the variations in potency are explained in terms of the binding mode revealed in the X-ray crystal structure. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1G4K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, HQQ and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http:// | + | 1G4K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=HQQ:'>HQQ</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4K OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Crowther, R.]] | [[Category: Crowther, R.]] | ||
[[Category: Dunten, P.]] | [[Category: Dunten, P.]] | ||
| - | [[Category: Foley, L | + | [[Category: Foley, L H.]] |
[[Category: Kammlott, U.]] | [[Category: Kammlott, U.]] | ||
[[Category: Levin, W.]] | [[Category: Levin, W.]] | ||
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[[Category: zinc ligand]] | [[Category: zinc ligand]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:04 2008'' |
Revision as of 10:46, 21 February 2008
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X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin
Contents |
Overview
A new class of matrix metalloproteinase (MMP) inhibitors has been identified by screening a collection of compounds against stromelysin. The inhibitors, 2,4,6-pyrimidine triones, have proven to be potent inhibitors of gelatinases A and B. An X-ray crystal structure of one representative compound bound to the catalytic domain of stromelysin shows that the compounds bind at the active site and ligand the active-site zinc. The pyrimidine triones mimic substrates in forming hydrogen bonds to key residues in the active site, and provide opportunities for placing appropriately chosen groups into the S1' specificity pocket of MMPS: A number of compounds have been synthesized and assayed against stromelysin, and the variations in potency are explained in terms of the binding mode revealed in the X-ray crystal structure.
Disease
Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[185250]
About this Structure
1G4K is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Stromelysin 1, with EC number 3.4.24.17 Full crystallographic information is available from OCA.
Reference
X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin., Dunten P, Kammlott U, Crowther R, Levin W, Foley LH, Wang P, Palermo R, Protein Sci. 2001 May;10(5):923-6. PMID:11316871
Page seeded by OCA on Thu Feb 21 12:46:04 2008
Categories: Homo sapiens | Single protein | Stromelysin 1 | Crowther, R. | Dunten, P. | Foley, L H. | Kammlott, U. | Levin, W. | Palermo, R. | Wang, P. | CA | GOL | HQQ | ZN | Mmp | Stomelysin | Zinc ligand
