2n87

<StructureSection load='2n87' size='340' side='right'caption='[[2n87]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2n87]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mnt 2mnt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N87 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2n84|2n84]]</div></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n87 OCA], [https://pdbe.org/2n87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n87 RCSB], [https://www.ebi.ac.uk/pdbsum/2n87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n87 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 (TbPar42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. TbPar42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of TbPar42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein.

Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei.,Rehic E, Hoenig D, Kamba BE, Goehring A, Hofmann E, Gasper R, Matena A, Bayer P Biomolecules. 2019 Mar 7;9(3). pii: biom9030093. doi: 10.3390/biom9030093. PMID:30866577<ref>PMID:30866577</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2n87" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bayer, P]]

[[Category: Rehic, E]]

[[Category: Ppiase domain]]