3w5w

<StructureSection load='3w5w' size='340' side='right'caption='[[3w5w]], [[Resolution|resolution]] 2.95&Aring;' scene=''>

<table><tr><td colspan='2'>[[3w5w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5W FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5w OCA], [https://pdbe.org/3w5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5w RCSB], [https://www.ebi.ac.uk/pdbsum/3w5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5w ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

NanoRNase (Nrn) specifically degrades nucleoside 3',5'-bisphosphate and the very short RNA, nanoRNA, during the final step of mRNA degradation. The crystal structure of Nrn in complex with a reaction product GMP was determined. The overall structure consists of two domains that are interconnected by a flexible loop and form a cleft. Two Mn(2)(+) ions are coordinated by conserved residues in the DHH motif of the N-terminal domain. GMP binds near the DHHA1 motif region in the C-terminal domain. Our structure enables us to predict the substrate-bound form of Nrn as well as other DHH/DHHA1 phosphoesterase family proteins.

Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins.,Uemura Y, Nakagawa N, Wakamatsu T, Kim K, Montelione GT, Hunt JF, Kuramitsu S, Masui R FEBS Lett. 2013 Aug 19;587(16):2669-74. doi: 10.1016/j.febslet.2013.06.053. Epub , 2013 Jul 9. PMID:23851074<ref>PMID:23851074</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3w5w" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Hunt, J F]]

[[Category: Kuramitsu, S]]

[[Category: Masui, R]]

[[Category: Montelione, G T]]

[[Category: Nakagawa, N]]

[[Category: Uemura, Y]]

[[Category: Wakamatsu, T]]

[[Category: Phosphatase]]