4jdy

<StructureSection load='4jdy' size='340' side='right'caption='[[4jdy]], [[Resolution|resolution]] 1.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[4jdy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JDY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jdy OCA], [https://pdbe.org/4jdy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jdy RCSB], [https://www.ebi.ac.uk/pdbsum/4jdy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jdy ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/PDXS_MYCTU PDXS_MYCTU]] Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity).

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Tuberculosis is a lethal infectious disease caused by Mycobacterium tuberculosis. We determined the crystal structure of Rv2606c, a potential pyridoxal biosynthesis lyase (PdxS), from M. tuberculosis H37Rv at 1.8A resolution. The overall structure of the protein, composed of a (beta/alpha)8-barrel and two small 310-helices, was quite similar to those of other PdxS proteins. A glycerol molecule was observed to be bound at the active site of the Rv2606c structure through interactions with the conserved residues of Asp29 and Lys86, providing information regarding the potential active site and the substrate-binding environment of the protein. The interface for Rv2606c dodecamerization, which is primarily mediated by salt bridges and hydrophobic interactions, was quite different from those of other PdxS proteins. Furthermore, we observed that the Rv2606c and Rv2604c form a stable complex, suggesting that these proteins might function as PdxS and PdxT in M. tuberculosis.

Crystal structure of Mycobacterium tuberculosis Rv2606c: A pyridoxal biosynthesis lyase.,Kim S, Kim KJ Biochem Biophys Res Commun. 2013 May 31;435(2):255-9. doi:, 10.1016/j.bbrc.2013.04.068. Epub 2013 Apr 30. PMID:23643787<ref>PMID:23643787</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 4jdy" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Kim, K J]]

[[Category: Kim, S]]

[[Category: Lyase]]