4afa

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<StructureSection load='4afa' size='340' side='right'caption='[[4afa]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='4afa' size='340' side='right'caption='[[4afa]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4afa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AFA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4afa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AFA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a3x|4a3x]], [[4af9|4af9]], [[4afb|4afb]], [[4afc|4afc]], [[4asl|4asl]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4afa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4afa OCA], [https://pdbe.org/4afa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4afa RCSB], [https://www.ebi.ac.uk/pdbsum/4afa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4afa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4afa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4afa OCA], [https://pdbe.org/4afa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4afa RCSB], [https://www.ebi.ac.uk/pdbsum/4afa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4afa ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6VBJ0_CANGB Q6VBJ0_CANGB]
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The human pathogenic yeast Candida glabrata harbors more than 20 surface-exposed, epithelial adhesins (Epas) for host cell adhesion. The Epa family recognizes host glycans and discriminates between target tissues by their adhesin (A) domains, but a detailed structural basis for ligand-binding specificity of Epa proteins has been lacking so far. In this study, we provide high-resolution crystal structures of the Epa1A domain in complex with different carbohydrate ligands that reveal how host cell mucin-type O-glycans are recognized and allow a structure-guided classification of the Epa family into specific subtypes. Further detailed structural and functional characterization of subtype-switched Epa1 variants shows that specificity is governed by two inner loops, CBL1 and CBL2, involved in calcium binding as well as by three outer loops, L1, L2, and L3. In summary, our study provides the structural basis for promiscuity and specificity of Epa adhesins, which might further contribute to developing anti-adhesive antimycotics and combating Candida colonization.
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Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia.,Maestre-Reyna M, Diderrich R, Veelders MS, Eulenburg G, Kalugin V, Bruckner S, Keller P, Rupp S, Mosch HU, Essen LO Proc Natl Acad Sci U S A. 2012 Oct 3. PMID:23035251<ref>PMID:23035251</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4afa" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Adhesin 3D structures|Adhesin 3D structures]]
*[[Adhesin 3D structures|Adhesin 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brueckner, S]]
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[[Category: Brueckner S]]
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[[Category: Diderrich, R]]
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[[Category: Diderrich R]]
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[[Category: Essen, L O]]
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[[Category: Essen L-O]]
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[[Category: Eulenburg, G]]
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[[Category: Eulenburg G]]
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[[Category: Kalugin, V]]
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[[Category: Kalugin V]]
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[[Category: Keller, P]]
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[[Category: Keller P]]
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[[Category: Maestre-Reyna, M]]
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[[Category: Maestre-Reyna M]]
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[[Category: Moesch, H U]]
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[[Category: Moesch H-U]]
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[[Category: Rupp, S]]
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[[Category: Rupp S]]
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[[Category: Veelders, M S]]
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[[Category: Veelders MS]]
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[[Category: Cell adhesion]]
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[[Category: Lectin]]
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[[Category: Pathogenicity]]
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[[Category: Tissue invasion]]
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Revision as of 07:14, 1 May 2024

Crystal Structure of subtype-switched Epithelial Adhesin 1 to 2 A domain (Epa1to2A) from Candida glabrata in complex with glycerol

PDB ID 4afa

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