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4akc

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Current revision (11:29, 20 December 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4akc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4akc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4ak4|4ak4]], [[4akb|4akb]], [[4akd|4akd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akc OCA], [https://pdbe.org/4akc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akc RCSB], [https://www.ebi.ac.uk/pdbsum/4akc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akc OCA], [https://pdbe.org/4akc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akc RCSB], [https://www.ebi.ac.uk/pdbsum/4akc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. [[https://www.uniprot.org/uniprot/LECB4_ARTIN LECB4_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum (By similarity).
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[https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Artocarpus integer]]
[[Category: Artocarpus integer]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abdul-Rahman, P S]]
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[[Category: Abdul-Rahman PS]]
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[[Category: Cogdell, R J]]
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[[Category: Cogdell RJ]]
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[[Category: Gabrielsen, M]]
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[[Category: Gabrielsen M]]
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[[Category: Hashim, O H]]
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[[Category: Hashim OH]]
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[[Category: Othman, S]]
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[[Category: Othman S]]
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[[Category: Mannose]]
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[[Category: Sugar binding protein]]
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Current revision

Structure of Galactose Binding lectin from Champedak (CGB) with Gal(beta)1,3-GalNac

PDB ID 4akc

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OCA

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