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4asi
From Proteopedia
(Difference between revisions)
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<StructureSection load='4asi' size='340' side='right'caption='[[4asi]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4asi' size='340' side='right'caption='[[4asi]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASI FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [https://pdbe.org/4asi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [https://www.ebi.ac.uk/pdbsum/4asi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [https://pdbe.org/4asi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [https://www.ebi.ac.uk/pdbsum/4asi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Froese DS]] |
| - | [[Category: Froese | + | [[Category: Kiyani W]] |
| - | [[Category: Kiyani | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Muniz JRC]] |
| - | [[Category: Muniz | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Vollmar M]] |
| - | [[Category: Vollmar | + | [[Category: Yue WW]] |
| - | [[Category: Yue | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of human ACACA C-terminal domain
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards A | Froese DS | Kiyani W | Krojer T | Muniz JRC | Oppermann U | Vollmar M | Yue WW | Von Delft F
