4asx

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Current revision (11:34, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4asx' size='340' side='right'caption='[[4asx]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='4asx' size='340' side='right'caption='[[4asx]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein_serine/threonine_kinase Receptor protein serine/threonine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.30 2.7.11.30] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [https://pdbe.org/4asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [https://www.ebi.ac.uk/pdbsum/4asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [https://pdbe.org/4asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [https://www.ebi.ac.uk/pdbsum/4asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN]] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
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[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Receptor protein serine/threonine kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Beltrami A]]
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[[Category: Beltrami, A]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Bracher F]]
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[[Category: Bracher, F]]
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[[Category: Bullock A]]
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[[Category: Bullock, A]]
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[[Category: Canning P]]
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[[Category: Canning, P]]
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[[Category: Chaikuad A]]
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[[Category: Chaikuad, A]]
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[[Category: Cooper CDO]]
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[[Category: Cooper, C D.O]]
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[[Category: Edwards AM]]
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[[Category: Delft, F von]]
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[[Category: Kochan G]]
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[[Category: Edwards, A M]]
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[[Category: Krojer T]]
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[[Category: Kochan, G]]
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[[Category: Mahajan P]]
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[[Category: Krojer, T]]
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[[Category: Pohl B]]
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[[Category: Mahajan, P]]
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[[Category: Williams E]]
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[[Category: Pohl, B]]
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[[Category: Von Delft F]]
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[[Category: Williams, E]]
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[[Category: Protein kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C

PDB ID 4asx

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OCA

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