1i16

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[[Image:1i16.jpg|left|200px]]
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{{STRUCTURE_1i16| PDB=1i16 | SCENE= }}
{{STRUCTURE_1i16| PDB=1i16 | SCENE= }}
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'''STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES'''
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===STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES===
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==Overview==
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The structure of a folded core of IL-16 is similar to that of intracellular protein modules called PDZ domains. IL-16 is thus the first extracellular protein found to have a PDZ-like fold. However, it does not exhibit normal peptide binding properties of PDZ domains. This is due to alterations of the structure at the 'PDZ-like binding site' of IL-16 (the GLGF cleft): the GLGF cleft of IL-16 is much smaller than those of PDZ-domains and is additionally blocked with a tryptophan side chain at its center. Our experiments indicate also that IL-16 nonspecifically aggregates in solution; but formation of a homo-tetrameric protein is not required, in contrast to previous suggestions, for its chemo-attractant activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 9699630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9699630}}
==About this Structure==
==About this Structure==
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1I16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I16 OCA].
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1I16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I16 OCA].
==Reference==
==Reference==
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[[Category: Lymphocyte chemoattractant factor]]
[[Category: Lymphocyte chemoattractant factor]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
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Revision as of 07:15, 1 July 2008

Image:1i16.png

Template:STRUCTURE 1i16

STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9699630

About this Structure

1I16 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site., Muhlhahn P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendorfer M, Lang K, Ambrosius D, Baier M, Kurth R, Holak TA, Nat Struct Biol. 1998 Aug;5(8):682-6. PMID:9699630

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