7va1

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'''Unreleased structure'''
 
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The entry 7va1 is ON HOLD until 2024-02-27
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==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35==
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<StructureSection load='7va1' size='340' side='right'caption='[[7va1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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Authors: Cen, Y., Gao, D., Zhou, J., Tian, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7va1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VA1 FirstGlance]. <br>
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Description: Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YP:4-[(3-ethanoylphenyl)sulfamoyl]-~{N}-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]benzamide'>5YP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7va1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7va1 OCA], [https://pdbe.org/7va1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7va1 RCSB], [https://www.ebi.ac.uk/pdbsum/7va1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7va1 ProSAT]</span></td></tr>
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[[Category: Cen, Y]]
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</table>
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[[Category: Gao, D]]
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== Disease ==
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[[Category: Zhou, J]]
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
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[[Category: Tian, P]]
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== Function ==
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cen Y]]
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[[Category: Gao D]]
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[[Category: Tian P]]
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[[Category: Zhou J]]

Revision as of 07:27, 8 March 2023

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35

PDB ID 7va1

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