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1i27

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{{STRUCTURE_1i27| PDB=1i27 | SCENE= }}
{{STRUCTURE_1i27| PDB=1i27 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''
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===CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)===
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==Overview==
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The x-ray structure of a C-terminal fragment of the RAP74 subunit of human transcription factor (TF) IIF has been determined at 1.02-A resolution. The alpha/beta structure is strikingly similar to the globular domain of linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3gamma (HNF-3gamma), making it a winged-helix protein. The surface electrostatic properties of this compact domain differ significantly from those of bona fide winged-helix transcription factors (HNF-3gamma and RFX1) and from the winged-helix domains found within the RAP30 subunit of TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative phosphatase binding site has been identified within the RAP74 winged-helix domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 11248041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11248041}}
==About this Structure==
==About this Structure==
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[[Category: Tfiif]]
[[Category: Tfiif]]
[[Category: Winged-helix domain]]
[[Category: Winged-helix domain]]
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Revision as of 07:18, 1 July 2008

Image:1i27.png

Template:STRUCTURE 1i27

CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)

Template:ABSTRACT PUBMED 11248041

About this Structure

1I27 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:11248041

Page seeded by OCA on Tue Jul 1 10:18:12 2008

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